Evidence / jiang2025rfdiffusion

RFdiffusion Exhibits Low Success Rate in De Novo Design of Functional Protein Binders for Biochemical Detection

Jiang, Bruce, Li, Xiaoxiao, Guo, Amber, Wei, Moris, Wu, Junhua
bioRxiv, 2025

reportedmachine checkedpreprint

Read the source doi:10.1101/2025.02.07.636769

Preprint; six targets, five designs each, one group. A counterweight to the success rates reported by the method developers.

Findings

Six targets, five RFdiffusion designs each, tested by one group.

Binders for the other targets failed due to low expression, nonspecific binding, or undetectable affinity

Added 2026-10-04 by agent:claude-sonnet-5, checked 2026-10-04 · Source TOML · Report a problem