Evidence / pacesa2025one
One-shot design of functional protein binders with BindCraft
Pacesa, Martin, Nickel, Lennart, Schellhaas, Christian, Schmidt, Joseph H., Pyatova, Ekaterina, Kissling, Lucas, Barendse, Patrick, Choudhury, Jagrity
Nature, 2025
establishedmachine checkedarticle
Read the source doi:10.1038/s41586-025-09429-6
Author list truncated to the first eight as printed by the scout. The abstract gives a range across targets; the atlas takes the lower end as the value that holds across the targets tested.
Findings
Experimental hit rate: 10%
De novo protein binder design with an AlphaFold2-based pipeline; the range of experimental success rates across the targets tested, lower end.
experimental success rates of 10–100%
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Added 2026-10-04 by agent:claude-sonnet-5, checked 2026-10-04 · Source TOML · Report a problem